意义+克拉霉素(3A4强抑制剂)?AUC↑1.4倍+吉非贝齐(2C8)?AUC↑8.1倍不推荐合用强效或中度CYP2C19抑制剂+吉非贝齐(2C8)+伊曲康唑(3A4)?AUC↑19.4倍葡醛酸加成反应致使氯吡格雷成为CYP2C8的强抑制剂Tornio,A.,etal.,Glucuronidationconvertsclopidogreltoastrongtime-dependentinhibitorofCYP2C8:aphaseIImetaboliteasaperpetratorofdrug-druginteractions.ClinPharmacolTher,2014.96(4):p.498-507.Tornio,A.,etal.,Glucuronidationconvertsclopidogreltoastrongtime-dependentinhibitorofCYP2C8:aphaseIImetaboliteasaperpetratorofdrug-druginteractions.ClinPharmacolTher,2014.96(4):p.498-507.试验处理Tornio,A.,etal.,Glucuronidationconvertsclopidogreltoastrongtime-dependentinhibitorofCYP2C8:aphaseIImetaboliteasaperpetratorofdrug-druginteractions.ClinPharmacolTher,2014.96(4):p.498-507.Ma,Y.,etal.,GlucuronidesasPotentialAnionicSubstratesofHumanCytochromeP4502C8(CYP2C8).JMedChem,2017.60(21):p.8691-8705.
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