on of procoagulants and platelets, and secondary activation of fibrinolysis. The resultant clinical condition is characterized by intravascular coagulation and hemorrhage.РCoagulation Hypercoagulable state ThrombusРFibrinolysis Hypocoagulable state HemorrhageРDiseases associated with DICРSepsis/severe infection 30% ?Malignancy 25%? solid and myeloproliferative malignancies ?plications 20%? Amniotic fluid embolism, Abruptio placentae? Retained dead fetus syndrome ?Trauma (neurotrauma) ,Organ destruction, Burns 15%?Severe hepatic failure?Rheumatologic illness? Adult Stills disease, Lupus ?Vascular abnormalities? Kasabach-Merritt syndrome, Large vascular aneurysms?HemolysisРTriggering factorsР① Release TF?② VEC injury?③ LPS?④ Ag-plexР⑤ Protease?⑥ Microparticles?⑦ Pathogenic Microbes (viruses)
全文预览
