高峰浓度出现的时间评价药物生物等效性重要依据之一。可有吸收延迟现象(Lagtime)。可有双峰现象,与肝肠循环有关。*评价药物生物等效性重要依据之一Whatifadrugisadministeredorallywithdifferentformulation?SolutionImmediaterelease(IR)tabletExtendedrelease(ER)tabletWhatifadrugisadministeredorallywithdifferentformulation?SolutionImmediaterelease(IR)tabletExtendedrelease(ER)tablettmax1.7tmax:timetoreachCmaxCmax96Cmax:rationtmax1.7Cmax96tmax:timetoreachCmaxCmax:maximumconcentrationWhatifadrugisadministeredorallywithdifferentformulation?SolutionImmediaterelease(IR)tabletExtendedrelease(ER)ration0.7133tmax1.7Cmax960.7133Whatifadrugisadministeredorallywithdifferentformulation?SolutionImmediaterelease(IR)tabletExtendedrelease(ER)rationtmax:timetoreachCmax5.0Cmax:maximumconcentration42ERtabletdisintegrationdissolutiondissolutionLagtime*药物吸收延迟现象t最高药物浓度最低药物浓度吸收延迟时间lgCLagtime
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