B,ZeltzerLK,Pediatric pain management.Nelson textbook of Pediatrics.17th ed. Elsevier Science,2004.358-365. Polaner DM, Sedation-analgesia in the pediatric intensive care unit. PediatriClin North Am,2001,48:695-715.理想镇静药物的特性The Children’s Hospital of Soochow University儿科镇静药物的选择?苯二氮卓类药物一直用于PICU镇静。?PICU中最常用的苯二氮卓类药物是咪唑安定、劳拉西泮及安定。?药物和缺氧可导致一些重症患者使用咪唑安定无效。?咪唑安定并不是一种绝对理想的镇静药物,其使用过程中主要的不良反应是耐受、依赖和停药后出现的戒断症状。?有证据表明,咪唑安定在低龄儿童中,镇静效果会下降Consensus guidelines on sedation and analgesia in critically ill children. Intensive Care Med,2006,32(8):1125-36. The Children’s Hospital of Soochow University儿科镇静药物的选择?推荐对大部分需要进行静脉镇静的重症患儿使用咪唑安定。应采用持续滴注方法给药。(推荐级别:C)?通过静脉滴注给药的可乐定,可以作为咪唑安定之外的备选镇静药物。(推荐级别:D)Consensus guidelines on sedation and analgesia in critically ill children. Intensive Care Med,2006,32(8):1125-36.