2020儿童脓毒性休克指南解读精华

seaseStudy,Lancet2020;395:200–11.全球脓毒症病死率KristinaERudd,Global,regional,andnationalsepsisincidenceandmortality,1990–2017:analysisfortheGlobalBurdenofDiseaseStudy,Lancet2020;395:200–11.全球儿童脓毒症发病率及病死率Fleischmann-StruzekC,GoldfarbDM,SchlattmannPetal(2018)Theglobalburdenofpaediatricandneonatalsepsis:asystematicreview.LancetRespirMed6:223–230全球儿童严重脓毒症病死率Fleischmann-StruzekC,GoldfarbDM,SchlattmannPetal(2018)Theglobalburdenofpaediatricandneonatalsepsis:asystematicreview.LancetRespirMed6:223–230儿童脓毒症流行病学特点儿童脓毒症每年约为22例/10万人;新生儿脓毒症为2202例/10万活产儿;脓毒症患儿的病死率4%-50%不等;死亡患儿多有难治性休克和/或多器官功能障碍综合征;多数死亡发生在治疗最初的48-72h内SurvivingSepsisCampaignInternationalGuidelinesfortheManagementofSepticShockandSepsis-anDysfunctioninChildren2020年,美国重症医师学会(SCCM)和欧洲危重病学会(ESICM)组成专家组提出新的《拯救脓毒症运动国际指南:儿童脓毒性休克和脓毒症相关器官功能障碍管理》目的设计及指南产生过程