c.upationalEnviromentalAbsorbandMetabolismAbsorb-Maybeabsorbedthroughrespiratoryordigestivetract-Alsothroughskin.Metabolism-Mainlyintheliver-byoxidation,detoxicationprocessesMechanismoftoxicactionTheAChE(acetylcholinesteraseofcholinesterase)binestheAChE,anophosphate-cholinesterase.causingacumilationofacetylcholine.ClinicalmanifestationsAcutepoisoning-Muscarinicsign:presentedwithconstraction,excessivelacrimalsecretion-Nicotinicsign:umulationof-CentralnervoussystemsignsAChEinneuromusculartransmissionDegreeofpoisoning-Mildpoisoning:Msign-Moderatepoisoning:Nsign,muscularfibrillation-a、pulmonaryedemabreathparalysis、anophosphateInducedDelayedPolyneuropathy(OPIDP)2~3weeks(4~45days)afterdisappearanceofacutesymptoms.ItisnotrelatedtotheinhibitionofChE,butisrelatedtoinhibitionofneuropathytargetedNTE.
全文预览
