reasedcreatininex1.FRdecrease>25%<0.5ml/kg/FRdecrease>50%<0.5ml/kg/FRdecrease>75%<0.3ml/kg/hx24horcreatinine≧4mg/dloranuriax12h(acuteriseof≧0.5mg/dl)pletelossofrenalfunction>4weeksESKDEnd-stagekidneydisease>3months婴幼儿肾脏发育特点新生儿肾脏发育及功能不成熟肾脏体积仅为成人的17%GFR为成人的1/4,到1~2岁时达到成人水平新生儿及婴幼儿肾小管重吸收功能差,易出现水及电解质紊乱。早产儿及足月新生儿的GFRAgeClearance(ml/minper1.73㎡)Pre-terminfants1-3days14.0±51-7days18.7±5.54-8days44.3±9.33-13days47.8±10.71.5-4months67.4±16.6Terminfants1-3days20.8±5.04-14days36.8±7.21-3months85.3+35.14-6months87.4±22.37-12months96.2+12.21-2years105.2±17.3早产儿及足月新生儿的血清肌酐平均值(μmol/L)生后时间(天)体重(g)1~28~915~1622~231001~1500956449351501~2000905850302001~250083473830足月66403027正常新生儿的尿量1-3ml/kg.h新生儿AKI流行病学特征新生儿AKI发生率为3.9/1000产;入院新生儿AKI发生率为34.5/1000产;新生儿AKI易感因素:-重度窒息新生儿-低体重(小于1500g)-低Apgar评分-动脉导管未闭-非甾体消炎药-母亲使用抗生素
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