ncreased acid secretionР2.NSAIDРAfter H.p infection, NSAID is the next important cause .? Research data show that NSAID use in patients with peptic ulcer and the risk plications was significantly higher than the general population. By weakening mucosal defense and repair functions eventually lead to peptic ulcer.Р案例展示Р4. Other risk factorsР1) Smoking ? Smoking is an increased risk of peptic ulcer. Smoking can affect the healing of ulcer, accelerate ulcer recurrence, and plication of ulceration. But the mechanism isn’t clear.Р2)Heredity ? Patients with peptic ulcer often have a family history of ulcer.And some studies show that blood group O(O型血人群) have a high risk to developing peptic ulcer .Р3)Stress High stress can stimulate vagus nerve(交感神经), which can result in high secretion of acid .