tomaticР% of normal clearance rate of CrРClinical?无症状РCCr GFR BUN BCr ? (%) (ml/min) (mmol/L) (umol/L)? >30 >50 <9 <178Р代偿期Р(1)Р失代偿期Р代偿期Р肾衰竭期Р尿毒症期РClinical manifestationРAsymptomaticР% of normal clearance rate of CrРClinical?乏力、轻度贫血、夜尿多РCCr GFR BUN BCr ? (%) (ml/min) (mmol/L) (umol/L)?25~30 25~50 9~20 178~445Р失代偿期Р(2)Р失代偿期Р代偿期Р肾衰竭期Р尿毒症期РClinical manifestationРAsymptomaticР% of normal clearance rate of CrРClinical?少尿、等渗尿、代谢性酸中毒РCCr GFR BUN BCr ? (%) (ml/min) (mmol/L) (umol/L)?20~25 <25 20~28 451~707Р肾衰竭期Р(3)Р失代偿期Р代偿期Р肾衰竭期Р尿毒症期РClinical manifestationРAsymptomaticР% of normal clearance rate of CrРClinical?各种尿毒症症状РCCr GFR BUN BCr ? (%) (ml/min) (mmol/L) (umol/L)? <20 <10 >28.6 >707Р尿毒症期Р(4)Р病因及发病机制Р原发性肾疾病Р继发性肾疾病Р慢性肾小球肾炎?慢性间质性肾炎?多囊肾?肾小管性酸中毒Р高血压肾小动脉硬化?糖尿病肾病?风湿性疾病?过敏性紫癜?痛风等Р病因及发病机制Р健存肾单位学说?矫枉失衡学说