Рimportance in ine development, has increased enormously in recent years. РThe major role of B-lymphocytes 1sthe production of antibodies of different Рisotypes and, of course, specrficity. The other classof lymphocytes, the T-cells, Рconsist of two main types. One, with the cell-surface marker CD4, exists in two Рsubclasses, the Thl- and ThZcells (h standing for helper activity). A major Рrole of Th2-cells is to “help” B-cells differentiate, replicate, and secrete anti- Рbody. They do this in part by the secretion of different cytokines (interleukins, РILs), which are listed in Table 4. Thl-cells also have a small, but important Рrole in helping B-cells produce antibody of certain isotypes, but the overall Рpattern of cytokine secretion is markedly different. Such factors asIEN-7, TNF-a,
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