roscope, with hematopoietic cells occupying <25% of the marrow space; in the most serious cases the biopsy is virtually 100% fat. ? It is required to establish the diagnosis. LOGO A .Normal bone marrow biopsy. This specimen shows an abundance of hematopoietic cells, including Myeloid and erythroid precursors and Normal-appearing megakaryocytes B. Aplastic anemia biopsy. This specimen shows few detectable hematopoietic cells, and those that can be seen (one small nest) are largely lymphocytes. LOGO 3.Bone marrow smear ? The bone marrow is usually readily aspirated but dilute on smear, and the fatty biopsy specimen may be grossly pale on withdrawal; In severe aplasia the smear of the aspirated specimen shows only red cells, residual lymphocytes, and stromal cells.
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