糖皮质激素与高血糖

e to stress by:АRaising blood glucose levelАModest rise in BP?Alter blood cell levels in plasma:АDecrease in eosinophils, basophils, monocytes and lymphocytes by redistribution from circulation to lymphoid tissueАIncrease in the number of RBC, platelets, neutrophilsРActions of GlucocorticoidsРAnti inflammatory action: (Complex mechanism)АSuppression of immunityАIndirect inhibition of phospholipase A2?Alter other endocrine systems:АDecrease in ACTH and TSHАIncrease in GH?Effects on other systems:АIncreased production of gastric acid, pepsinАEffects SАBone lossАMyopathyРActions…Cont.Р糖皮质激素因其多种生物学作用被广泛用于临床多种疾病的短期或长期治疗?“双刃剑”:发挥治疗作用的同时,也不可避免的引起一些副作用,血糖异常便是其中常见的情况之一?了解其发病规律、临床特性及治疗策略对于在临床上合理、安全运用皮质激素,避免或者有效控制高血糖具有重要意义Р类固醇性糖尿病(Steroid diabetes)?内源性肾上腺皮质类固醇分泌增多,或外源应用糖皮质激素所导致的继发性糖尿病?一种特殊类型的糖代谢紊乱综合征