be an or multisystem diseases ?can be more than one autoantibody in a given disease ?lossРCauses for Loss of self-tolerance?Bypass of helper T-cell tolerance ?modification of antigen (via drugs, anisms) ?expression of second signal from macrophages stimulated from infections ?Molecular mimicry ?infectious agents appear similar to self-antigens (al antigen and myocardium)?Polyclonal lymphocyte activation ?endotoxins cause such activation independent of specific antigensРImbalance of suppressor-helper T cell function ?any loss of suppressor T-cell function may contribute to autoimmunity ?Emergence of sequestered antigens ?following trauma or infection, previously unseen antigens may emerge (bullous pemphigoid following a burn)РThe immunity regulatesРOrgan-specific diseases?Systemic diseases
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