t we do know?我们所知的:РAnaesthetics alone can cause POCD in mice after repeated exposure反复使用麻醉药这一单一因素即可导致小鼠术后认知功能的障碍?Anaesthetics can alter hippocampal gene expression lasting weeks, indicating that longer term intracellular changes occurs麻醉药能够持续数周改变海马基因的表达,提示发生了远期的细胞内改变РBianchi SL, Tran T, Liu C et al. Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics. Neurobiol Aging 2007.?Culley DJ, Yukhananov RY, Xie Z et al. Altered hippocampal gene expression 2 days after general anesthesia in rats. Eur J Pharmacol 2006;549:71-8.РWhat we don’t know- what is the trigger for harm我们不知道的–导致伤害的诱因是什么?РDrug药物?Dose剂量?Depth麻醉深度?Duration用药时间?Repeated exposure反复用药?Patient susceptibility病人的易感性?Importance of co-morbidities并存疾病的重要性?Are all anaesthetics equal???所有的麻醉药都一样吗?
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