tion of heat an of heat an?Body temperature is higher than that of set point?Non-regulated elevation of body temperature?Passive elevation of body temperature, ?degenerative disease of hypothalamus, ichthyosis of skin, heat stoke, hyperthyroidismРClassification ( according to increasing extent of body temperature)?Low-grade fever: <38 ℃?Middle-grade fever: 38- 39 ℃?High-grade fever: 39-40 ℃?Superhigh-grade fever: >40 ℃РFever is a regulated elevation of body temperature caused by upper shift of set point at the effect of pyrogen.РExogenous pyrogensРEndogenous pyrogens (cytokines)РEndogenous pyrogens-produced cellРproduce, releaseРThermoregulatory centerРSet point shifts upward, body temperature elevatesРNon-microbial pyretic substancesРPyrogenic activatorsРⅠetiologyРⅡpathogenesisРmechanism?
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