MiRNA与血小板活性的研究进展：一个新的评估抗血小板治疗效果的潜在生物标志物

609-1616.22 Aradi D, Storey RF, Komócsi A, et al. Expert positionpaper on the role of platelet function testing in patientsundergoing percutaneous coronary intervention[J].Eur Heart J, 2014, 35:209-215.23 Voora D1, Ginsburg GS, Akerblom A. Platelet RNAas a novel biomarker for the response to antiplatelettherapy[J]. Future Cardiol, 2014, 10:9-12.24 Willeit P, Zampetaki A, Dudek K, et al. CirculatingmicroRNAs as novel biomarkers for plateletactivation[J]. Circ Res, 2013, 112:595-600.25 Stratz C, Nührenberg TG, Binder H, et al. Micro-arrayprofiling exhibits remarkable intra-individual stabilityof human platelet micro-RNA[J]. Thromb Haemost,2012, 107:634-641.miRNA对抗血小板药物的反应性方面仍未完全达至一致。现况而言,需要更多的相关研究进一步补充临床样本中miRNA对抗血小板药物反应性的数据。此外,除了着重于抗血小板过程中miRNA与血小板活性的定性研究,如何定量地评估两者的关系并绘制具有临床应用价值的相关曲线显得尤为重要。