pandSalinemodelgroupratsdecreased,amplitudeincreased,thecoefficientofvariationofslowwavefrequencyandamplitudewassignificantlyhigherthanthatofnormalgroupandtreatmentgroup.Numberofintramuralganglionsignificantlyreducedandsignificantfibrosisinmodelgroupandsalinecontrolgroup.Relativecontentsofc—kitmRNA,SCFmRNAofmodelgroupandsalinecontrolgroupweresignificantlyreduced.Conclusions:Simotangcansignificantlysuppresstheinfluenceofdrugsonmodelingslowtransitconstipationrats,suchasslowingcolonicmyoelectricslowwavefrequency,increasingtheamplitudeandthe矗equencyandamplitudevariationcoefficient,reducingthenumberofgangliaandfibrosisandbyincreasingthec—kitmRNArelativecontent,SCFmRNArelativecontenttotreatslowtransitconstipation.KEYWORDS:slowtransitconstipation,Simotang,clinicalresearch,experimentalstudy一7-万方数据
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