acobson S, Keene J, et al. Multiple biomarkersР8 文富强, 陈磊. 中国慢性阻塞性肺疾病诊疗的现存问题与思Р 考[J]. 中华医学杂志,2020,100(2): 81-84. predict disease severity, progression and mortality in COPD[J].Р Respir Res,2017,18(1): 117.Р9 Rennard SI, Drummond MB. Early chronic obstructive pulmonaryРР disease: definition, assessment, and prevention[J]. Lancet , 21 di Marco F, Sotgiu G, Santus P, et al. Long-acting bronchodilatorsР 2015,385(9979): 1778-1788. improve exercise capacity in COPD patients: a systematic reviewР and meta-analysis[J]. Respir Res,2018,19(1): 18.