滞可以产生镇静作用,表现为对丙泊酚敏感性增加和用量减少。椎管内阻滞产生镇静效应最有可能的机制是去传人作用(spinal deafferentation)。【关键词】蛛网膜下腔阻滞;布比卡因;丙泊酚;镇静 Effect ot Subarachnoid Bupivacaine Block on Sedation of Propofol in Rats 【Abstract】Objective To investigate the effects of subarachnoid bupivacaine block on sedation of propofol in rats and probe into its possible mechanism.Methods 20 included Sprague—Dawley(so)rats were in this study.After intrathecal catheter placement individually,rats were randomly divided into experimental group(Bupivacaine group)and control group(Normal saline group)in a crossover design study.Each rat received either 20 micro liter of 0.75%bupivacaine or 20 micro liter of normal saline intrathecallv, intravenous infusion of propofol started 1 0 minutes after intrathecal at injection,the dosage and onset time 0f 378.
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