人卫第八版《诊断学》实验诊断学_止血和血栓

stasis?2.Classification of Bleeding Disorders?3.Laboratory TestsРBook 1:《实验诊断学》(供八年制、七年制)P.125-153/P.104-130?Book 2:Use and Assessment of Clinical Laboratory Results ( Lothar Thomas,2004,上海科学技术出版社)Р止血、凝血的机制Р小血管、微血管(smll vessel)?血小板(platelet)?凝血系统(coagulation protein system)?抗凝系统(anticoagulation protein system)?纤溶系统(fibrinolysis system)?抗纤溶系统(antifibrinolysis system)РHemostasisРCoagulation?ActivationРBV InjuryРPlatelet?ActivationРPlt-FusionРBlood Vessel ?ConstrictionРStable Hemostatic PlugРThromibn,?FibrinРReduced?Blood flowРTissue FactorРPrimary hemostatic plugРNeuralР止血的过程Р(一)Blood Vessel System?1.通过神经反射使血管收缩。?2.激活血小板释放TXA2、5-HT、ET等使血管收缩。?3.分泌vWF(von Willbrand factor)、血小板激活因子PAF、TXA2。?4.因子Ⅻ激活启动内源性凝血系统;因子Ⅲ释放启动外源性凝血系统。?5.内皮细胞释放u-PA, t-PA-抗纤溶作用。Р止血的过程Р(二)Platelet SystemР(三)Coagulation System