ize5,6,7,8一tetrahydroquinolineintheautoclavewithO—allylcyclohexanoneoximewhichispreparedbyoneself,itisstudiedeffecttothesynthesiswhennitrogenandoxygencoexist.Theyieldofre—arrangementisupto26·7%·3.Itisstudiedthattakingthemethodof“cook—together7’toreactwith7-ACA,1,1,1,3,3,3-hexamethyldisilazaneandtrimethyliodosilanewhichthenbeesterifiedbyMAEMandacidifiedbyvitriol,Cefquinomeisgottenfinallywiththeyieldof20.1%.4.Itisstudiedthattakingthemethodof“cook—together’’toreactwith1,1,1,3,3,3.hexamethyldisilazaneandtrimethyliodosilaneandtheoriginalmaterialcefotaximepreparedbyoneselfintoCefquinomeHIsalt,whichthenbeionexchangedwithcationexchangeresin,Cefquinomesulfateisgottenfinallywiththetotalyieldof46.5%.1VKey?Words:?5,6,7,8一Tetrahydroquinoline,cefotaxime,?antibacterial,cefquinome,synthesisV北京化工大学硕士学位论文VI
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