帕金森病综合诊断课件

dyN=12,401+2Re-studyN=1,188NegativesymptomquestionnaireN=27,213ResponseN=29,454Parkinson’sDiseaseN=277*N=17N=6N=252*N=2PositivesymptomquestionnaireN=2,241ParkinsonismexcludedN=27,212EligibleN=31,318Non-responseN=1,864NeurologicalexamN=2,241NeurologicalexamN=27,212+1Lost3,323Died873Follow_upSurveyForNon-PDParkinsonismnon-follow-upn=49,traced=62.3%*ForPDnon-follow-upn=75traced=72.5%94%64.4%45.6%33.8%43.7%56.3%66.2%6/14/20195临床诊断的准确性22年中,65例尸检,59例神经病理检查。生前临床最初诊断PD43例,随访11.7年,临床最后诊断PD41例死后病理证实31(76%)。(Rajput,etal.1991)6/14/20196病理检查确认? 临床误诊为PD的原因6/14/20197神经病理诊断59例6/14/20198疑似特发性帕金森病的?主要的特发性帕金森综合症6/14/20199ClinicalDiagnosisofIPD:difficult,particularlyinearlycasesBetweenIPDandotherparkinsoniansyndrome.ClinicallydiagnosedIPD:100casesPathologicallyconfirmed:76cases(HughesAJ,etal.1992)6/14/201910