teristics ?during chronic HBV infectionРViral reservoir?cDNAРThe persistent HBV replicationРThe accumulation of HBV antigens in vivoРCharacteristics in liver pathology in chronic hepatitis BРLymphoctyes?Plasma cells?MacrophagesРFibrosis?Liver cirrhosisРDegradation?NecrosisРAtalas of the Liver, Maddrey WC, 3rd EditionРInflammation?infiltrationРNK and Kuffer cells?activated HSC?Epithelial cellsРT cells?NK, MΦ,?Treg, PD-1РHCCРImpairment of specific T cellsРImpairment & Disorder of immune ?responses in CHB patientsРImpairment of Ag presentationРAbnormal B-cell responsesРSuppressive?factors increased: Treg and PD-1РHyper-activated NK, Th17 immunity inducing liver injuryРSpecific Immune?Responses РNon-Specific Immune?Responses РHost Immune?DisorderРB cellРT cellРTh17 cellРTreg cellРNK cell
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