nk细胞淋巴瘤讲义课件

No single marker unequivocally identifies all NK cellsРCD2 70-90%?s-CD3 0%?c-CD3>95%?CD4 0%?CD5 0%?CD7 80-90%?CD8 30-40%РCD11b* 80-90%?CD16* 80-90%?CD56* >95%?CD57* 50-60%?CD25 >95%Р* Commonly used NK markers,?but expressed in both NK cells?and NK-like T cellsРDiscrepancy of CD3 expression?in NK cellsРCD3 is a TCR-plex?Formed by 6 chains: , , 2, 2?NK cells have cytoplasmic  or , but cannot assemble intact plex?Conventional CD3 antibody detects  chain “cytoplasmic CD3”РSurface CD3 (as detected by Leu4/OKT3) by flow cytometry or on frozen tissue is NEGATIVEРTCRРLeu4, OKT3Р结外NK/T细胞淋巴瘤,鼻型Рa鼻腔、鼻咽部、鼻窦及腭部最常见,皮肤、软组织、胃肠道和睾丸亦常见。?b鼻腔者表现为鼻塞、鼻衄,粘膜坏死及溃疡。皮肤病变表现为结节并多伴有溃疡。发生在肠道者常发生穿孔。?c肿瘤常有噬血管性,多伴有血管破坏和坏死。?d常坏死明显,活检取材要取及非坏死瘤组织,常需多次取材才能确诊。Р大多数病例为EBV(+)、CD56(+)的NK细胞表型,而少数病例具有EBV(+)、CD56(-)的细胞毒性T细胞表型。