Strategies for Fine Mapping & cloning 2bpencil@ Most of the important morphological ,physiological and agronomical traits are quantitative traits, which are always analyzed by QTL napping . What ’ s QTL ? Statistic method Quantitative trait QTL3 QTL2 QTL1 gene 1 gene 3 gene 2 gene 7 gene 6 gene 5 gene 4 expression Abundance of available molecular markers facilitate the detection of ic fundamental of quantitative traits Two Steps For QTL Analysis STEP 1 : From Phenotype to QTL Primary Mapping Fine mapping STEP 2 : From QTL to Gene QTL--QTG--QTN STEP 1 STEP 2 Strategies for Fine Mapping & cloning QTLs Still a challenge work • Polygene & minor effect • Complicated epistasises • G x E Solution • Advanced mapping population • Progeny test Fine mapping
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