ics in cancer肿瘤世界癌症现状世界癌症现状全球(2010年)809 万人死亡1303 万新发病例5肝癌1肺癌7食道癌3结肠癌2乳腺癌4胃癌6宫颈癌CancerCancer6宫颈癌5结肠癌8鼻咽癌1肺癌2肝癌7乳腺癌3胃癌4食道癌268 万新发病例中国癌症现状中国癌症现状197 万人死亡中国(2010)What causes cancer?What causes cancer?Carcinogenesis. Carcinogenesis. Some factors to considerSome factors to consider……??HeredityHeredity??ImmunityImmunity??ChemicalChemical??PhysicalPhysical??Viral Viral ??BacterialBacterial??LifestyleLifestyleHeredity Heredity ??Genes isolated for Genes isolated for several classic familial several classic familial cancer syndromes:cancer syndromes:––RB1 (retinoblastoma)RB1 (retinoblastoma)––APC (familial polyposis)APC (familial polyposis)––Human Non Polyposis Human Non Polyposis Colon Cancer ()Colon Cancer ()––BRCA 1&2 (breast BRCA 1&2 (breast cancer)cancer)––p53 (many cancers)p53 (many cancers)