99概述?Definition of ics?Any changes in gene expression resulting from either a DNA and chromatin modification or resulting from a post post-transcriptional mechanism. However, it does not reflect a difference in the DNA code。?A unifying definition of ics: (Adrian Bird, nature, 2007)?the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states. ?This definition is inclusive of chromosomal marks, because transient modifications associated with both DNA repair or cell-cycle phases and stable changes maintained across multiple cell generations qualify.2016年11月20日992016年11月20日1010概述?表观遗传学的特点:?可遗传的,即这类改变通过有丝分裂或减数分裂,能在细胞或个体世代间遗传;?可逆性的基因表达调节,也有较少的学者描述为基因活性或功能的改变;?没有DNA序列的改变或不能用DNA序列变化来解释。2016年11月20日1010
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