表观遗传学课件

gene expression resulting from either a DNA and chromatin modification or resulting from a post post- transcriptional mechanism. However, it does not reflect a difference in the DNA code 。? A unifying definition of ics : (Adrian Bird, nature, 2007) ? the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states. ? This definition is inclusive of chromosomal marks, because transient modifications associated with both DNA repair or cell-cycle phases and stable changes maintained across multiple cell generations qualify. 2017 年3月 17 日 9 9 2017 年3月 17 日 10 10概述?表观遗传学的特点: ?可遗传的,即这类改变通过有丝分裂或减数分裂,能在细胞或个体世代间遗传; ?可逆性的基因表达调节,也有较少的学者描述为基因活性或功能的改变; ?没有 DNA 序列的改变或不能用 DNA 序列变化来解释。 2017 年3月 17 日 10 10