d warranted, theРselection of empiric antifungal therapy (e. g., fluconazole, 2c. We bination therapy for patients withРamphotericin B, or echinocandin) will be tailored to the known or suspected Pseudomonas infections asРlocal pattern of the most prevalent Candida species, and a cause of severe sepsis (Grade 2D).Рany prior administration of azoles drugs [44]. Risk factors 2d. We bination empiric therapy for neu-Рfor candidemia should also be considered when choosing tropenic patients with severe sepsis (Grade 2D).Рinitial therapy. 2e. When used empirically in patients with severe sepsis,Р Because patients with severe sepsis or septic shock we suggest bination therapy should not be ad-Рhave little margin for error in the choice of therapy, ministered for more than 3 to 5 days. De-escalation
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