c-Abl非受体酪氨酸激酶与U2AF65相互作用及其生物学意义论文

nuclear-cytoplasmicshuttlingprotein,andc-AblregulatesionizingirradiationinducedshuttlebetweenthenucleusandthecytoplasmofU2AF65.U2AF65hasnuclearexportsignal(NES)andthecharacteristicsequenceis’LCLMNMVLP’.IonizingirradiationregulatesU2AF65’snuclearandcytoplasmicshuttlinginducedmRNAtransport.c-Ablwidelyinfluencestheregulationoftranscriptionandalternativesplicing.Inconclusion,ourfindingsdemonstratedthatc-AblcouldassociatewithU2AF65,inadditiontophosphorylatingthefactor.c-AblmaybeabletoregulateU2AF65nuclear-cytoplasmicshuttlingandmRNAtransport.Andc-Ablmayalsobeinvolvedintheregulationoftranscriptionandalternativesplicing.Thisstudyismeaningfulforelucidatingthefunctionofc-Ablundernormalorstressconditions.Keywords:c-Abl;U2AF65;Nuclear-Cytoplasmicshuttling;mRNAtransport;Alternativesplicing;ExonarrayIV