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线粒体融合蛋白Mitofusin 在胰岛素抵抗发生与防治中的作用

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004, 114Р energy expenditure. Diabetologia, 2007, 50(11): 2348-55 (10): 1518-26Р[36] Soyal S, Krempler F, Oberkofler H, et al. PGC-1α: a potent [39] Cartoni R, Léger B, Hock MB, et al. Mitofusins 1/2 and ERRР transcriptional cofactor involved in the pathogenesis of type α expression are increased in human skeletal muscle afterР 2 diabetes. Diabetologia, 2006, 49(7): 1477-88 physical exercise. J Physiol, 2005, 567(Pt 1): 349-58Р[37] Mootha V, Lindgren C, Eriksson K, et al. PGC-1α-respon- [40] Garnier A, Fortin D, Zoll J, et al. Coordinated changes inР sive genes involved in oxidative phosphorylation are coordi- mitochondrial function and biogenesis in healthy and dis-Р nately downregulated in human diabetes. Nat , 2003, eased human skeletal muscle. FASEB J, 2005, 19(1): 43-52Р 34(3): 267-73

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