dendrocytes,andothernervoussystemcells.3.Theearlyandlateapoptosisrateintransplantationgrouparelessthanmodelgroup,theexpressionofBcl一2intransplantationgrouparehigher,butthetheexpressionofBaxarelowerthanthemodelgroup,easedanddecreasedtheexpressionofBax,thedifferencehaveastatisticalsignificance.4.haninthecontrolgroup,thedifferencehaveastatisticalsignificance.Coneludion1.MSCsandNSCscanbecultured,ellsandproducedBDNFandNGE2.BeingtransplantatedMSCstOencephalocoeleCanimprovesignificantlypathologicalandfunctionalconditionofHIBD,transplantationofMSCshaveanexacttherapyrolestOHIBDrats.KeywordsHypoxic—ischemicbraininjury;Animalmodel;Neuralstemcells;Mesenchymalstemcell;transplantation;co-culture.Keywords:Hypoxic-ischemicbraininjury;Animalmodel;Mesenchymalstemcell;Transplantation;Apoptosis;Behaviorscore.