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miRNA-9通过Notch通路调控骨性关节炎软骨细胞增殖和分化的机制研究211

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究竟其通过何种途径影响 Notch 信号通路,还有待进一步的证实和研究。Р 参考文献Р [1]Goldoni D, Yarham JM, McGahon MK, et al. A novel du al-fluorescence strategy for functionally validating microRNA targets in 3’untranslated regions: regulation of the inward rectier potassium channel K(ir)2.1 by miR-212. Biochem J, 2012, 448(1): 103-113 .Р [2]Lu J,Luo H,Liu X,et a1.miRNA-9 targets CXCR4 and functions as a potential Tumor suppressor in nasopharyugeal carcinoma[J].Carcinogenesis,2014,35(3):554-563.Р [3]Song J,Kim D,Chun CH,et a1.MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin [J].mun Signal,2013,11:66.Р [4]Conrad S,Genth H,Hofmann F,et a1.Neogenin-RGMa signaling at the growth cone is bone ic protein--independent and involves RhoA,ROCK,and PKC[J].J Biol Chem,2007,282(22):16423-16433.

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