Group 2 innate lymphoid cells promote beiging of?white adipose tissue and limit obesity?ILC2促进白色脂肪组织棕色化并抑制肥胖РNature?15.4.12РLetterРFat metabolismРGlycerine+3 fatty acidРacetyl-CoAРmitochondrionРUcp1РOxiРCO2+H2O+EР①Insulin?②Gluconeogenesis?③Gluconeogenesis?④Few?⑤Abnormal (Over intake, Diabetes)Р(蛋白质)РBREGРDCregРLin-ST2+CD127+CD25+?GATA3+РILC2 developmentРID2 - TCF-7 –γc - IL-5+IL-13РHuman AB WAT:ILC2РMurine AB WAT:ILC2Р人和鼠的脂肪组织中均含有?ILC2。Р年长女性肥胖者较多,但是其规律与ILC2数量没有明显相关性。Р高脂肪饮食小鼠相比对照组饮食小鼠,ILC2含量明显下降。РAge:7WРHFD or CD for 12WРILC2Р2abc ex2ab:IL-33敲除后,ILC2数量下降?且IL-13、IL-5下降。?2d 敲除IL-33后,10天体重变化上升РCommon dietРILC2, BWРIL-33 KO or not
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