esweighing1000–1500gbyimplementingevidence-basedfeedingprotocols.Itmaybenotedthatsomebabies,especiallythoselessthan1000grams,willnottoleratelargervolumesoffeedings(suchas180mL/kg/dayormore)andthusmayneedindividualization.RationaleReachingfullenteralfeedingfasterresultsinearlierremovalofvascularcatheters,andlesssepsisandothercatheter-plications(LOE2b).esinVLBWI.Reachingfullfeedswithinaweekisachievable—inanRCTonVLBWI,themediantimetoreach170mL/kg/daywas7daysafterfastadvancementofenteralfeeding,withnoincreaseinapneas,feedinterruptions,andintolerance.喂奶频次建议:建议1250g以上早产儿每3小时喂奶一次。1250g以下早产儿尚无足够证据决定选择每隔3小时喂奶还是每隔2小时喂奶。依据:在一项随机对照研究中,92名出生体重<1750g的新生儿随机分为隔3小时喂养组和隔2小时喂养组,两组间喂养不耐受、呼吸暂停、低血糖、坏死性小肠结肠炎(NEC)发生率无统计学差异,隔3小时喂养组花在喂奶上的时间少于隔2小时喂养组(LOE2b)。另外两个回顾性研究得出的结论相反,一项研究认为隔3小时喂养和隔2小时喂养效果相似,另一项研究认为隔2小时喂养更有益处。