er, bowel, inguinal node, distant metastasisРEndometrial Cancer: FIGO Surgical StageРEndometrial Cancer Prognosis:РSurvival by Stage:РStageР% 5yr survivalРIAР91РIBР88РICР81РIIAР77РIIBР67РIIIAР60РIIIBР41РIIICР32РIVAР20РIVBР5РSurvival by Grade:РGradeР% 5yr survivalР1Р92Р2Р87Р3Р74РOverall 5Yr Survival 84%?Stage and Grade are the most important prognostic factors?Altered oncogene/tumor suppressor gene expression is now being evaluated (molecular staging concept)РAggressive Histologic Subtypes (Clear-cell, Serous)?Increasing age (over 65)?Vascular invasion?Aneuploidy?Altered oncogene/tumor suppressor gene expression ( “molecular staging” concept- p53, PTEN, microsatellite instability, MDR-1, HER2/neu, ER/PR, Ki 67, PCNA, CD 31,EGF-R, MMR genes) ?Race?РEndometrial Cancer: Poor Prognostic Factors
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