ions,icregulatorsresultinanalteredepigenome.表观遗传过程的改变可以导致基因突变,基因突变的表观遗传调节结果是基因组突变。TheprognosticandpredictivevaluesofthemethylationstatusoftheMGMTpromoterandIDHstatushaveshiftedtheGBMclassificationtoamolecular-basedclassificationthathasclinicalimplicationsandrelevance.MGMT启动子的甲基化状态和IDH突变状态的预后和预测值价值已经改变了胶质母细胞瘤的分类至分子水平,具有临床意义和相关性。However,asofyet,nomolecularprofiling–e.然而,迄今为止,在针对不同的治疗策略的选择和患者预后的判断方面,还没有基于分子基础的GBM的分类。ic-mediatedsilencingofMGMTandhasbeenconfirmedinmultipleclinicaltrialsasanimportantpredictivegenomicbiomarkerinthecontextofalkylatingagentssuchastemozolomide.itisalsooneofthemostimportantprognosticfactorsforprogression-freesurvivalandoverallsurvivalinpatientswithGBM.IDH1mutationscanhelpdifferentiateprimaryfromsecondaryGBMsandportendabetterprognosisinpatientswhoharborthesemutations.
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