whichassembletoformachannel,aconnexon.~20differentisoformsofconnexinsinhumansandmiceGapjunctionUsedbymostcellsinanimaltissueswiththeexceptionofafewterminallydifferentiatedcells,anicionsandothersmallwater-solublemoleculestopassdirectlyfromonecelltotheother,ursatchemicalsynapsesThesharingofsmallmetabolitesandionsprovidesamechanismforcoordinatingtheactivitiesofindividualcells(ooperation)2.FunctionofGapJunction3.GapJunctioninDiseasesConnexingenemutationandDiseasesCongenitalnon-syndromaticdeafness(Cx26mutation)Congenitalcataract(Cx50mutation)Axonaldegenerationofperipheralnerves(Cx32mutation)Infertilityoffemales(Cx37)Gapjunctionandtumorpromotion--municationdown-regulated--connexintransfectionforup-regulationGapjunctionandembryogenesis--embryodevelopment(Cx43)--nutrientstransportation(Cx26)Others
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