us ?abortion %РMaternal age at conceptionРAndersen NAM et al. Maternal age and fetal loss: population based register ?Linkage study. Br Med J; 24: 1708-12Р自发性流产与年龄关系РMaternal age at conceptionРRisk of ?stillbirthРAndersen NAM et al. Maternal age and fetal loss: population based register ?Linkage study. Br Med J; 24: 1708-12Р死胎风险与年龄关系Р卵母细胞数量与年龄关系(折棍效应)Р后天因素Р先天因素Р卵泡衰老、生殖功能减退Р卵泡闭锁速率取决于剩余卵泡池的大小?剩余卵泡池在达到临界值时卵泡闭锁速率显著加快. ?卵泡质量同步降低 Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF (1992): ? Accelerated disappearance of ovarian follicles in midlife;? implications for forecasting Menopause. Hum Reprod 7, 1342-1346Р折棍效应的意义Р(step reductions of follicle numbers)РFaddy MJ. Follicle dynamics during ovarian ageing. Mol Cell Endocrinol 2000 163:43-48Р免疫因素Р感染因素Р医源性因素Р环境因素Р卵泡池达到临界值后,卵泡的质、量同步下降速度显著快速增加
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