原发中枢神经系统淋巴瘤

mg+Dex5mg美罗华30~50mg+Dex2mgB方案AMTX3~5g/m2,d1VCR2mg,d1Ifosfomide800mg/m2,d2~4Dex10mg/m2,d2~4方案BCarmustine125mg,d1Teniposide50mgorEtoposide100mg,d1~3Vindestine4mg,d1Dex20mg,d1~4W9Cycle1Cycle2W10Cycle1Cycle2AB*±美罗华500-600mgweekly×4-6Cycle3疗效评估治疗前后神经精神症状、体征的变化。每2-3个月复查脑CT、MRI或PET。CSF随查。ResponseBrainImagingCorticosteroidsDoseEyeExaminationCSFCytologyCRNocontrastenhancementNoneNormalNegativeCRuNocontrastenhancementMinimalabnormalityAnyAnyNormalMinorRPEabnormalityNegativePR50%decreaseinenhancingtumorNocontrastenhancementIrrelevantIrrelevantMinorRPEabnormalornormalDecreaseinvitreouscellsorretinalinfiltrateNegativePersistentofsuspiciousPD25%pleteresponse;CRu,pleteresponse;RPE,retinalpigmentepitheliumPR,partialresponse;PD,progressivediseaseAbreyLE,etal.JCO2005,23:5034-SlymphomaCollaborativeGroup,2004