外周t细胞淋巴瘤治疗进展

7表达缺失(最常见),CD5缺失?CD4>CD8, CD4-CD8-,CD4+CD8+?B淋巴细胞抗原表达阴性PTCL-NOS细胞分子遗传学特点?PTCL-NOS无特征性细胞遗传性异常?采用PCR技术可测得TCR基因重排?染色体重排或缺失?通常累及6,7,9,13,17和14号染色体临床分期?Ann Arbor-Cotswold 改良分期体系适用于淋巴结起病为主的T细胞淋巴瘤?其他T细胞淋巴瘤的分期体系(结外起病为主)?原发胃肠淋巴瘤分期(Musshoff/Lugano分期)?皮肤蕈样霉菌病/Sezary综合征(MF/SS)分期(TNMB)?皮肤其他类型淋巴瘤(非MF/SS)分期(TNM)?NK/T细胞淋巴瘤分期?Nasal vs. non nasal vs. leukemiaCarbone.PP, Kaplan HS, Musshoff K, et al. Cancer Res. 1971;31:1860Lister TA, et al. J Clin Oncol. 1989; 7:1630; ISCL及EORTC体系.Blood, 2007;110:6; Kwong, et al. Blood, 2013 May; 121: 4997-5005.ProportionTimeIPICENSORFAILTOTALMEDIAN0/1 36 47 835.032 36 67 103 2.13 20 53 731.414/5 9 38 470.68 Test: p<0.0010.00.10.20.30.40.50.60.70.80.91.00123456789101112131415161718PTCL-NOS Cases by IPI预后评分:IPI/PIT