基于“芳香亲核取代-重排”...检测生物活性分子的荧光探针 王斯雨

physiologicalprocessesrespectivelyandtheabnormalchangesofdistributionandconcentrationareoftenrelatedtotheР pathologicalprocessofmanydiseases.ThesimilarstructuresandreactivityofthesebiothiolsbringgreatchallengesforР theirselectivedetection.Inrecentyears,themechanismof“aromaticnucleophilicsubstitution-rearrangement”hasbeenР developedasageneralstrategyfortheselectivedetectionofbiothiols,andhasbeenextendedtothedetectionofotherР bioactivemolecules.Inthiswork,thedesign,synthesis,andapplicationoffluorescentprobesbasedonthismechanismР arereviewed.Р Keywords: fluorescentprobes,aromaticnucleophilicsubstitution-rearrangement,biothiols,proteaseР doi: 10.1360/SSC-2022-0024Р 20