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整合素α5β1及其信号转导通路在慢性乙型肝炎肝纤维化中的作用

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ve dependences on PCIII,IVC,HA and LN俨<O.0 1),respectively.РConclusions:1 From a clinical point of view,at the level of cells and proteins,we have attested that liver tissue integrin a513 l,FAK,FN,a-SMA and TGF·13 1 play important roles in the formation of heoatichepatic fibrosis。chronictibrosis in chronic he》atitisnepatms B,md, ano havenave aРpositive relationship with the degree of hepatic fibrosis.TheirРexoressiveness l。S conducive to the diagnosis or h印atic tibrosts·Р2 Wre have studied the formation mechanism of the chronic hepatitis B hepatic fibrosis at the signal transduction level.It canРbe concluded that the integrin and the induced signalРtransduction pathways are closely related with FIAK,which play significant roles on the HSC activation and the formation of hepatic fibrosis.Р9

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