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肠促胰岛素类药物Exendin-4的研究综述

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etaminophen)administeredatvarioustimesinrelationtosubcutaneousinjectionofexenatide(exendin-4)inhealthysubjects.JClinPharmacol.2005May;45(5):570-7.[23]PeptidebindingattheGLP-1receptor.BiochemSocTrans.2007Aug;35(Pt4):713-6.[24]DifferentialstructuralpropertiesofGLP-1andexendin-heirrelativeaffinityfortheGLP-1receptorN-terminalextracellulardomain.Biochemistry.2007May15;46(19):5830-40.Epub2007Apr20.[25]Amodelforreceptor-peptidebindingattheglucagon-likepeptide-1(GLP-1)receptorthroughtheanalysisoftruncatedligandsandreceptorsBritishJournalofPharmacology(2003)140,339-346[26]ProlongingtheActionofProteinandPeptideDrugsbyaNovelApproachofReversiblePolyethyleneGlycolMod讦ication.THEJOURNALOFBIOLOGICALCHEMISTRYVol.279,No.37,IssueofSeptember10,pp.38118-38124,2004[27]DruckerDJ,etal.Lancet.2008;372:1240-1250.

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