体外循环心肌保护方法的研究进展

,以期望为临床提供一种药物,维持高危患者长期处于理想的保护状态,这具有积极的临床意义。由于心脏搏动下心内直视手术温度维持在34℃,没有中低温过程,已经运用成熟的体外循环血液稀释晶胶体比例预充技术等理论是否适应仍在探讨中。目前多数的心脏医生认为心脏迅速冷停搏可提供一个安静无血的手术视野,便于操作,效果确切,易于掌握。主张将心脏冷停搏技术作为心肌保护的常用方法。Р【ngen GA.Ischemic preconditioning:from molecular characterization to clinical application-part I[J].Neth J Med,2004,62(10):353~363.Р [13]Miura T,Iimura.Infarct size limitation by preconditioning:its phenomenological features and the key role of adenosine[J].Cardi-ovasc Res,1993,27(1):36~42.Р [14]Toyoda Y ,Di Gregorio V,Parker RA,et a1.Anti-stunning and anti-infarct effects of adenosine-enhanced ischemic precondi- tioning[J].Circulation,2000,102(19 SuppIⅢ):326~331.Р [15]Shinj i ental study on myocardial protection by adjunct use of carperitide (hANP) in cardiac surgery[J].Ann Thorac Cardiovasc Surg,2005,11:12~20.