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单克隆抗体靶向治疗类风湿关节炎的新进展

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(5):669-681.Р [15] Genovese M C,Mckay J D,Nasonov EL,et al. Interleukin-6 receptor inhibition withР tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs:the tocilizumab bination with traditional disease-modifying antirheumatic drug therapy study[J]. Arthritis Rheum,2008,58(10):2968-2980.Р [16] Hueber W, Patel DD, Dryja T, et al. Effects of AIN457, a fully human antibody to interleukinР -17A, on psoriasis, rheumatoid arthritis, and uveitis[J]. Sci Transl Med,2010,2:52-72.Р [17] Bongartz, T. et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of seriousР infections and malignancies: systemic review and meta-analysis of rare harmful effects in randomized controlled trials[J]. JAMA ,2006,295, 2275–2285.

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