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慢病毒介导的稳定表达HBx促进HepG2细胞增殖

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].VirolJ.2012,9:163.[16]WangFZ,FeiHR,LianLH,etal.HepatitisBx-interactingproteininducesHepG2cellproliferationthroughactivationofthephosphatidylinositol3-kinase/Aktpathway[J].ExpBiolMed(Maywood).2011,236:62-69.[17]KhattarE,MukherjiA,KumarV.AktaugmentstheoncogenicpotentialoftheHBxproteinofhepatitisBvirusbyphosphorylation[J].FEBSJ.2012,279:1220-1230.[18]GearhartTL,BouchardMJ.ThehepatitisBvirusHBxproteinmodulatescellcycleregulatoryproteinsinculturedprimaryhumanhepatocytes[J].VirusRes.2011,155:363-367.[19]GearhartTL,BouchardMJ.ThehepatitisBvirusXproteinmodulateshepatocyteproliferationpathwaystostimulateviralreplication[J].JVirol.2010,84:2675-2686.[20]GearhartTL,BouchardMJ.ReplicationofthehepatitisBvirusrequiresacalcium-dependentHBx-inducedG1phasearrestofhepatocytes[J].Virology.2010,407:14-25.-9-

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