inicalPracticeGuideline:InterpretationofExhaledNitricOxideLevelsforClinicalApplications,AmJRespirCritCareMed2011184.pp602–615;Usingfractionalexhalednitricoxide(FeNO)todiagnosesteroid-responsivediseaseandguideasthmamanagementinroutinecare,ClinicalandTranslationalAllergy2013,3:37;BjermerL,etal.,CurrentevidenceandfutureresearchneedsforFeNOmeasurementinrespiratorydiseases,RespiratoryMedicine(2014),http://dx./10.1016/j.rmed.2014.02.005鼻呼气一氧化氮(FnNO)检测空气进入抽出分析FnNO测定方法:将鼻橄榄头置入一鼻孔由仪器恒速(10ml/s)抽气10s,另一鼻孔自由进气。该恒速气流将携带鼻腔与鼻窦产生的NO进入仪器分析测定。FnNO检测测试时必须保持软腭关闭,(防止下呼吸道气体进入上呼吸道)采用下面的一种方法防止下呼吸道气体进入上呼吸道:口含吹嘴呼气>10cmH2O吹笛式口呼气(类似于吹口哨)(推荐)口憋气(方便,但可靠性差)鼻窦>1000ppb鼻腔<100ppb气道5-50ppb肺泡<5ppb因此,高浓度NO可从鼻部上气道经循环或鼻后滴漏路径扩散至肺部下气道,使FeNO升高:同一气道、同一炎症FnNO=鼻腔NO+(鼻窦NO)x(鼻窦口径)/流速FnNO升高:鼻窦口开放的上气道炎症(轻度鼻炎鼻窦炎)FnNO降低:鼻窦口堵塞的上气道炎症(重度鼻炎鼻窦炎)
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