无特异性,与传统意义肝癌(肝细胞癌、胆管细胞癌)鉴别困难。?2、诊断仍然依赖于病理学和免疫组化染色(IHC)。? 神经元特异性烯醇化酶(NSE)? 突触素(Syn)? 嗜铬粒蛋白A (Cg A)?的首选检测指标应是CgA,因其敏感性和特异性都很高(敏感性51%~54%,特异性79%~87%)[5-6]远远高于其他免疫组化标记物,而且对于肿瘤患者的预后及长期监测有一定的指导作用[7]。Р[5] HIJIOKA M, ITO T, IGARASHI H, et al. Serum chromo-granin A is a useful marker for Japanese patients with pancreatic neuroendocrine tumors [J]. Cancer Sci, 2014, 105(11): 1464-1471. ?[6] MASSIRONI S, ROSSI R E, CASAZZA G, et al. Chromo-granin A in diagnosing and monitoring patients with gastroen-teropancreatic neuroendocrine neoplasms: a large series from a single institution [J]. Neuroendocrinology, 2014, 100(2-3): 240-249.?[7] YALAV O, ÜLKÜ A, AKCAM T A, et al. Primary hepatic neuroendocrine tumor: Five cases with different preoperative diagnoses [J]. Turk J Gastroenterol, 2012, 23(3): 272-278.
全文预览
