ts?Peptide receptor therapy?Liver metastasis:? Surgical Intervention、TACEРOctreotideРSymptoms of flushing and diarrhea relieved in 75-80%?50% e refractory?Stabilize disease in 50%?Tumor regression in 4%РArnold R et al. Digestion. 1993;54(suppl 1):72-75.РInterferonРInterferon alpha?Biochemical response in 40%?Stabilizes tumor in 15-40%?Tumor regression in 12%?Toxicity:?Fatigue、Myelosuppression、Fever、Flu-like illness?DepressionРÖberg K. Ann Oncol. 2001;12(suppl 2):S111-S114.?Shnirer, II, et al. Acta Oncol 2003;42:672-692.РChemotherapyРGenerally ineffective?Low mitotic rate?High bcl-2 expression?MDR gene expression?Agents?Streptozocin+Doxorubicin+Fluoropyrimidines RR30%?DTIC:First line RR33% Second line 8%?Temozolamide±xeloda RR35-40%?Poor-differentiaed CIS/L-OHP+VP-16 RR40-60% with short PFS
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